MACROCYCLIC STEREOCONTROL
Introduction
Background
Conformational Control in Medium-Sized Rings
Asymmetric Synthesis with Medium-Sized Rings
Case Studies in Natural Products Total Synthesis
Macrocyclic Stereocontrol in Cyclic Peptides
Appendix: Macrocycle Formation
CARBONYL ADITION REACTIONS
Introduction
Non-Chelated 1,2-Asymmetric Induction and the Operation of Steric and Electronic Effects
1,2-Asymmetric Induction Predicated on Chelation Control
1,3-Asymmetric Induction from CBeta Stereogenic Centers
Asymmetric Induction by Remote Stereocenters (Beyond 1,3-Induction)
Catalytic Enantioselective Carbonyl Additions of Arganozinc Species
Enantioselective Ketone Reduction
Enzymatic Reduction of Ketones
Enantioselective Formation of Cyanohydrins
Enantioselective Alkyne Additions
Asymmetric Carbonyl-Ene Reactions
ALPHA-FUNCTIONALIZATIONS OF ENOLATES
Introduction
Diastereoselective Alpha-Alkylations of Chiral Enolates
Heteroatom-Substituted Enolates
Asymmetric Enolate Alkylations Using Chiral Auxiliaries
Enantioselective Enolate Alkylations
Alpha-Hydroxylations of Enolates
Alpha-Halogenations of Enolates
ALDOL REACTIONS
Introduction
Chiral Enolates Through the Use of Chiral Auxiliaries or Chiral Controller Groups
Substrate Control with Chiral Carbonyl Compounds
Catalytic Enantioselective Aldol Reactions
ALLYLATIONS OF C=O BONDS
Introduction
Reactivity of Allylmetal Reagents
Boronate Additions
Enantioselective Additions of Optically Active Allylic Boron Reagents
Diastereoselecive Allylations with Chiral Boron Reagents
Mechanistic Aspects - Lewis Acid-Promoted Addition of Allylsilanes and Allylstannanes to Aldehydes
Chelation Control in the Allylation of Alpha- and Beta-Alkoxy Aldehydes
Allylchromium Reagents
Diastereoselective Allylations with Chiral Silanes and Stannanes
Catalytic Asymmetric Allylations
CHIRAL ACETALS
Introduction
Diastereoselective Reactions of Chiral Acetals
Glycosylations
Spiroketals in Natural Product Synthesis
ALKENE HYDROBORATION
Introduction
Hydroborations with Acyclic Stereocontrol
Metal-Catalyzed Hydroborations
Asymmetric Hydroborations with Chiral Boranes
Catalytic Asymmetric Hydroboration, Hydrosilylation, and Hydroalumination
REDUCTIONS OF OLEFINS
Introduction
Diastereoselective Olefin Reductions by Catalytic Hydrogenation
Alternative Methods for Diastereoselective Olefin Reductions
Catalytic Asymmetric Olefin Hydrogenations
OXIDATIONS OF OLEFINS
Introduction
Diastereoselective Epoxidations
Enantioselective Epoxidations
Asymmetric Ring-Opening of Epoxides
Synthesis of Aziridines
Iodolactonizations and Other Olefin Cyclizations Induced by Electrophiles
Diastereoselective Dihydroxylations of Olefins
Enantioselective Dihydroxylations of Olefins
Enantioselective Aminohydroxylation of Olefins
AMINO ACIDS
Introduction
Enantioselective Hydrogenations of Alpha, Beta-Didehydroamino Acids
Enolate Alkylations in the Presence of Chiral Auxiliaries
Alkylation of Glycine Anion Equivalents in the Presence of Chiral Phase-Transfer Catalysts
Enolate Aminations
Enzymatic Syntheses of Alpha-Amino Acids
Catalytic Asymmetric Strecker Reactions
ADDITIONS TO C=N BONDS
Introduction
Substrate-Controlled Diastereoselective Additions to C=N Bonds
Additions to Imine Derivatives Bearing N-Bound Auxiliaries
Formation of Beta-Lactams Through Staudinger Reactions
Intramolecular Diastereoselective Iminium Ion Cyclizations
Pictet-Spengler Reactions
Catalytic Asymmetric Reductions of Imines and Imine Derivatives
Catalytic Enantioselective Mannich and Mannich-Type Reactions
Enantioselective Additions of Carbon Nucleophiles to C=N Bonds
CONJUGATE ADDITIONS
Introduction
Diastereoselective Conjugate Additions
 
Diastereoselective Conjugate Additions with Use of Chiral