PREFACE PART 1: CONCEPTS A Brief Introduction to Traditional Bioconjugate Chemistry [3+2] Dipolar Cycloadditions in Bioconjugation Diels-Alder and Inverse Diels-Alder Reactions The Staudinger Ligation Thiol-Ene Chemistry Ligand-Directed Tosyl and Acyl Imidazole Chemistry Bioorthogonal Labeling of Cellular Proteins by Enzymatic and Related Mechanisms Metal-Mediated Bioconjugation PART 2: APPLICATIONS Protein and Antibody Labeling Activity-Based Protein Profiling Nucleic Acid Labelling, Ligation, and Modification Chemoselective Reactions for Glycan Labeling Chemoselective Attachment of Lipids to Proteins In Vivo Applications of Bioorthogonal Chemistries Immobilization of Biomolecular Probes for Arrays and Assay: Critical Aspects of Biointerfaces Chemical Ligations in the Design of Hydrogel Materials Nanoparticle Bioconjugates: Materials that Benefit from Chemoselective and Bioorthogonal Ligation Chemistries Application of Engineered Viral Nanoparticles in Materials and Medicine ukryj opis