PART 1 - Introduction to Protein therapeutics: past and present Early recombinant protein therapeutics Evolution of antibody therapeutics PART 2 - Antibodies: the ultimate scaffold for protein therapeutics Human antibody Structure and Function Antibodies from other species PART 3 - Discovery and engineering of protein therapeutics Human antibody discovery platforms Non-antibody scaffolds and antibody mimetics Protein engineering: methods and applications Bispecifics Antibody-drug conjugates PART 4 - Physiological and manufacturing considerations for biologics Pharmacokinetics Safety Considerations for Biologics Immunogenicity Expression Systems for manufacture Stability, formulation and deliveryPART 5 - Clinical applications Protein therapeutics in autoimmune and inflammatory diseases Protein therapeutics in oncology Protein therapeutics in respiratory diseases Protein therapeutics in infectious diseases and other indications Rescue therapies Biosimilars PART 6 - Future horizons Future horizons and new target class opportunities ukryj opis