Part I Basic Research for Innovative Medicine.- 1. Diverting Glycolysis to Combat Oxidative Stress.- 2. Metabolic Regulation by Nuclear Receptors.- 3. Fighting Fire with Fire in Cancer.- 4. Linear Polyubiquitination: a Crucial Regulator of NF- k B Activation.- 5. VCP, a major ATPase in the cells, as a novel drug target for currently incurable disorders.- 6. Roles of E-cadherin in hepatocarcinogenesis.- 7. The Hippo Signaling Pathway: A Candidate New Drug Target for Malignant Tumors.- 8. Inhibitory immunoreceptors on mast cells in allergy and inflammation.- 9. Doxycycline-inducible Autoimmune Blistering Skin Disease Model.- 10. T-cell Senescence and Autoimmunity.- Part II Translational Research for Innovative Medicine .- 11. IL-6: A new era for the treatment of autoimmune inflammatory diseases.- 12. Pathogenesis of Non-alcoholic Steatohepatitis and Its Potential Therapeutic Strategies.- 13. Multifaceted translational approach of major mental illness.- 14. Translational research of leptin in lipodystrophy and its related diseases.- 15. Translational research of the activation of the C-type natriuretic peptide (CNP)-guanylyl cyclase-B pathway for skeletal dysplasia.- 16. Clarity and Challenges in Tissue Fibrosis.- 17. TRP Channels: Their Function and Potentiality as Drug Targets.- 18. Autophagic Cell Death and Cancer Chemotherapeutics.- 19. Adrenomedullin as a Potential Therapeutic Agent for Refractory Ulcerative Colitis.- 20. RNA activation.- Part III New Technology for\nInnovative Medicine.- 21. Cardiac Reprogramming for Heart Repair.- 22. Development of a new in vivo optical probe for biological diagnosis and therapy.- 23. Introduction of mesenchymal stem cells for liver surgery (hepatectomy and transplantation).- 24. Synaptic and axonal plasticity induction in the human cerebral cortex.- 25. TIM-3 is a novel therapeutic target for eradicating acute myelogenous leukemia stem cells.- 26. TGF-beta LAP degradation products, a novel biomarker and promising therapeutic target for liver fibrogenesis.- 27. Cell-based regenerative therapy for liver disease.