Preface-1. Introduction - 2. Pharmacology: Mechanism of Action of Bisphosphonates- 3. Use of Bisphosphonates in Oncology, Hematology and Osteoporosis - 4. Biomorphology in BIONJ: Anatomy and History - 5. Ethiopathogenesis and clinic of BIONJ - 6. Instrumental Diagnosis.- 7. Microbiological Aspects - 8. Prevention and role of Dentist - 9. Conservative Treatment: Oxygen, Ozone and Laser - 10. Minimally Invasive Surgical Treatment - 11. Major Surgery in BIONJ - 12. The future of BIONJ