Chapter 1. A new approach to early breast cancer (Tibor Tot and Zsuzsanna Kahán). Chapter 2. Screening of breast cancer (Per Skaane). Chapter 3. Magnetic resonance imaging (MRI) in screening high-risk patients and in detecting and diagnosing early breast cancer (Gábor Forrai). Chapter 4. Large-format histology, a prerequisite for adequate assessment of early breast carcinomas (Tibor Tot). Chapter 5. The molecular evolution of breast cancer precursors and risk indicators (Paul M Wilkerson, Konstantin J Dedes, Maria A Lopez-Garcia, Felipe C Geyer and Jorge S Reis-Filho. Chapter 6. Immunohistochemistry and molecular biology of breast cancers; Old and new prognostic factors (Konstantin J. Dedes, Paul Wilkerson and Jorge S. Reis-Filho). Chapter 7. Sentinel node biopsy and nodal staging (Gábor Cserni). Chapter 8. Tailored surgery: Limited breast and lymph node surgery (György Lázár). Chapter 9. Radiotherapy: A new approach to risk-adapted selective radiotherapy (Csaba Polgár). Chapter 10. The risks of radiotherapy and how to avoid them (Zsuzsanna Kahán, Katalin Hideghéty and Zoltán Varga). Chapter 11. Systemic adjuvant therapy for Stage I breast cancer (Lajos Pusztai and Catherine M. Kelly). Chapter 12. Systemic therapy: Selection of patients. Endocrine therapy (Zsuzsanna Kahán).