History of Tobacco.- Epidemiology of Tobacco Dependence.- Tobacco Constituents and Additives.- Pharmacology and Pharmacokinetics of Nicotine.- Smoking and Lung Disease.- Cardiovascular Disease, Disturbances of Blood Coagulation and Fibrinolysis.- Other Organ Systems.- Smoking and Pregnancy.- Passive Smoking.- Non-Drug Treatments to Promote Smoking Cessation.- Pharmacotherapy of Nicotine Dependence.- Primary Prevention.- Tobacco Industry, Advertising and Advertising Bans.- Society, Politics and the Tobacco Industry.- Appendix: Experiences from a Smoker Counselling Centre.