Part 1: CENTRAL CONCEPTS OF PATHOPHYSIOLOGY: CELLS AND TISSUES

Unit I: THE CELL

1. Cellular Biology

2. Altered Cellular and Tissue Biology: Environmental Agents

3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases

Unit II: GENES AND GENE-ENVIRONMENT INTERACTION

1. Genes and Genetic Diseases

2. Genes, Environment-Lifestyle, and Common Diseases

3. Epigenetics and Disease

Unit III: MECHANISMS OF SELF-DEFENSE

1. Innate Immunity: Inflammation

2. Adaptive Immunity

3. Alterations in Immunity and Inflammation

4. Infection

5. Stress and Disease

Unit IV. CELLULAR PROLIFERATION: CANCER

1. Cancer Biology

2. Cancer Epidemiology

3. Cancer in Children

Part 2: PATHOPHYSIOLOGIC ALTERATIONS: ORGANS AND SYSTEMS

Unit V: THE NEUROLOGIC SYSTEM

1. Structure and Function of the Neurologic System

2. Pain, Temperature Regulation, Sleep, and Sensory Function

3. Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function

4. Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction

5. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders

6. Alterations of Neurologic Function in Children

Unit VI: THE ENDOCRINE SYSTEM

1. Mechanisms of Hormonal Regulation

2. Alterations of Hormonal Regulation

3. Obesity and Disorders of Nutrition NEW

Unit VII: THE REPRODUCTIVE SYSTEMS

1. Structure and Function of the Reproductive Systems

2. Alterations of the Female Reproductive System

3. Alterations of the Male Reproductive System

4. Sexually Transmitted Infections

Unit VIII: THE HEMATOLOGIC SYSTEM

1. Structure and Function of the Hematologic System

2. Alterations of Erythrocyte, Platelet, and Hemostatic Function

3. Alterations of Leukocyte and Lymphoid Function

4. Alterations of Hematologic Function in Children

Unit IX: THE CARDIOVASCULAR AND LYMPHATIC SYSTEMS

1. Structure and Function of the Cardiovascular and Lymphatic Systems

2. Alterations of Cardiovascular Function

3. Alterations of Cardiovascular Function in Children

Unit X: THE PULMONARY SYSTEM

1. Structure and Function of the Pulmonary System

2. Alterations of Pulmonary Function

3. Alterations of Pulmonary Function in Children

Unit XI: THE RENAL AND UROLOGIC SYSTEMS

1. Structure and Function of the Renal and Urologic Systems

2. Alterations of Renal and Urinary Function

3. Alterations of Renal and Urinary Tract Function in Children

Unit XII: THE DIGESTIVE SYSTEM

1. Structure and Function of the Digestive System

2. Alterations of Digestive Function

3. Alterations of Digestive Function in Children

Unit XIII: THE MUSCULOSKELETAL SYSTEM

1. Structure and Function of the Musculoskeletal System

2. Alterations of Musculoskeletal Function

3. Alterations of Musculoskeletal Function in Children

Unit XIV: THE INTEGUMENTARY SYSTEM

1. Structure, Function, and Disorders of the Integument

2. Alterations of the Integument in Children

Unit XV: MULTIPLE INTERACTING SYSTEMS

1. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults

2. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children